I'm a physiologist by academic training, my research priorities include synaptic, behavioral and circuit level alteration in neurodegeneration like Alzheimer's disease (AD), tauopathies.
Alzheimer's is known to characterized by extracellular amyloid plaque and intracellular neurofibrillary tangle deposition in brain parenchyma. Which is implicated with patient's cognitive impairment and have direct association with synaptic dysfunction.
Currently I'm postdoctoral researcher at Center for Alzheimer's research at division of clinical geriatrics, Karolinska Institutet, Stockholm, Sweden with Dr Amit Kumar. Previously, I've worked with Dr Christophe Mulle in the team Synapses and Neural Circuits in Behaviour at IINS (UMR5297), Bordeaux Neurocampus, France.
Alzheimer's is known to characterized by extracellular amyloid plaque and intracellular neurofibrillary tangle deposition in brain parenchyma. Which is implicated with patient's cognitive impairment and have direct association with synaptic dysfunction.
Currently I'm postdoctoral researcher at Center for Alzheimer's research at division of clinical geriatrics, Karolinska Institutet, Stockholm, Sweden with Dr Amit Kumar. Previously, I've worked with Dr Christophe Mulle in the team Synapses and Neural Circuits in Behaviour at IINS (UMR5297), Bordeaux Neurocampus, France.
My PhD thesis investigated the role of non-invasive brain stimulation in animal model of AD. Thesis title: ‘‘A morphological and functional study on intracerebroventricular streptozotocin induced rat model of Alzheimer’s disease: Effect of magnetic field stimulation’’. This work was conducted in Neurophysiology and nano-medicine lab with Dr Suman Jain in All India Institute for Medical Sciences, New Delhi.
Expertise
Currently I'm involved in developing and validating a novel tool to image synaptic dysfunction in tauopathies as well as in other related motor neurodegenrations in post-motem brain samples from human brain. Read more for details.
Previously I was involved in understanding the role of genetic risk factor phospholipase gamma 2 beyound glia. Where we found new insight into the role of the aforementioned risk factor in association with Alzheimer's disease.
Soft skills includes, analysis of ephys results in Igor pro, Neuromatic, open-ephy-python-tool and FIJI, Imaris, NeuroStudio and others for imaging experiments.
Previously, I used to do cognitive tasks with rodents. Also microinjection through stereotaxic surgeries in brain areas (like hippocampus, lateral ventricles, hypothalamus etc.). Also I did different histological tools (Nissl, Golgi-COX, Congo-red) including immunostaining for sub-cellular localisation of proteins, biochemicals tools (ELISA, western blot), 1H-NMR, transmission electron microscopy.
During this period I came across different softwares related to the aforementioned tools like Ethovision XT, AnyMaze, FIJI, Neurolucida, Neurolucida-explorer, Mnova, TopSpin, Espina, webknoss, python, SPSS, graphpad etc.
Previously I was involved in understanding the role of genetic risk factor phospholipase gamma 2 beyound glia. Where we found new insight into the role of the aforementioned risk factor in association with Alzheimer's disease.
Soft skills includes, analysis of ephys results in Igor pro, Neuromatic, open-ephy-python-tool and FIJI, Imaris, NeuroStudio and others for imaging experiments.
Previously, I used to do cognitive tasks with rodents. Also microinjection through stereotaxic surgeries in brain areas (like hippocampus, lateral ventricles, hypothalamus etc.). Also I did different histological tools (Nissl, Golgi-COX, Congo-red) including immunostaining for sub-cellular localisation of proteins, biochemicals tools (ELISA, western blot), 1H-NMR, transmission electron microscopy.
During this period I came across different softwares related to the aforementioned tools like Ethovision XT, AnyMaze, FIJI, Neurolucida, Neurolucida-explorer, Mnova, TopSpin, Espina, webknoss, python, SPSS, graphpad etc.
Journal role
Apart from doing experimental neuroscience I'm also involved in reviewing papers in peer review journals as ad-hoc reviewer in journals like Neurochemical Research; Journal of Chemical Neuroanatomy; International Journal of General Medicine; Frontiers in Neuroscience (sec. Gut brain axix); Frontiers in Aging Neuroscience (sec. Neurocognitive Aging and Behavior); Molecular Biology reports; Alzheimer’s research and therapy; Molecular neurobiology; BMC Neuroscience; Scientific Reports, Probiotics and anti-microbial protein.
Education
Bachelors in Science Physiology University of Calcutta (2013)
Masters in Science Human Physiology University of Calcutta (2015)
Doctor of Philosophy Neurophysiology All India Institute for Medical Sciences (2022)
My origin
I come from a middle class Bengali family from Eastern India. I've born in Jangipur, a small village in former capital of Bengal, Murshidabad state. A place situated near stone trow distance from neighbouring SAARC nation country Bangladesh in a semi-autonomous ruler family of that region.
Till then travelled to different places of West Bengal namely Asansol, Bosoa, Rampurhat, Kolkata and few more as my father was a running staff in Indian railway. Frankly speaking, after having a change of school at least 10-11 times in my childhood now it is hard for me to choose my school, but I was lucky to have so many teachers in my life keeping my zeal to science always on top. Subsequently, I came Delhi to pursue my PhD and now in Bordeaux, France for my first postdoc.
Till then travelled to different places of West Bengal namely Asansol, Bosoa, Rampurhat, Kolkata and few more as my father was a running staff in Indian railway. Frankly speaking, after having a change of school at least 10-11 times in my childhood now it is hard for me to choose my school, but I was lucky to have so many teachers in my life keeping my zeal to science always on top. Subsequently, I came Delhi to pursue my PhD and now in Bordeaux, France for my first postdoc.
Contact
Avishek Roy
Postdoctoral researcher
Center for Alzheimer's research, Neurobiology Care Sciences and Society
Karolinska Institutet
7th Floor, Blickagangen 16, Neo, Huddinge, Stockholm